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Print version ISSN 0120-4157On-line version ISSN 2590-7379


CANTILLO, Jorge de Jesús; LOPEZ, Rocío del Pilar  and  ANDRADE, Rafael Enrique. Nonamyloidotic glomerular disease caused by light chain deposits: a case report. Biomédica [online]. 2009, vol.29, n.4, pp.531-538. ISSN 0120-4157.

The nephropathy of monoclonal gammopathies is principally caused by light chain deposits of fragmented immunoglobins. Paraprotein-related renal diseases are associated with such deposits of intact (heavy chain) or fragmentary (light chain) immunoglobins. A condition of pathological light chain deposits is rare and characterized by deposits of fragments of monoclonal immunoglobulins in many organs. Renal deposits occur primarily in glomeruli and tubular basement membranes. This disease is frequently associated with lymphoproliferative disorders. The majority of cases are caused by deposits of kappa light chains. Whereas this disease is most frequently associated with hematologic malignancies, occasionally a case occurs without detectable hematological pathologies; these cases are called idiopathic or primary. They usually manifest themselves as severe renal insufficiencies with nephrotic-range proteinuria. No treatment regime has been clearly established and the prognosis is poor. Herein, the clinical and histological characteristics are described regarding the first case in Colombia of light chain deposit disease without symptoms of malignancy.

Keywords : Kidney diseases; paraproteinemias; immunoglobulin light chains; case reports.

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