SciELO - Scientific Electronic Library Online

vol.31 issue2Mechanisms of human natural resistance to HIV: A summary of ten years of research in the Colombian population author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand



Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google



Print version ISSN 0120-4157
On-line version ISSN 2590-7379


ARBOLEDA, John F; GARCIA, Luis F  and  ALVAREZ, Cristiam M. ILT3+/ILT4+ tolerogenic dendritic cells and their influence on allograft survival. Biomédica [online]. 2011, vol.31, n.2, pp.281-295. ISSN 0120-4157.

Dendritic cells, the most powerful antigen-presenting cells, are important for triggering of the immune responses to allo-antigens. However, they also play a fundamental role in the peripheral tolerance maintenance. Tolerance is enhanced by the presence on the dendritic cell surface of the inhibitor receptors ILT3 and ILT4. They recruit protein tyrosine-phosphatases to their ITIM domains and inhibit antigen-presenting cell activation, leading T cell hypo-responsivensess. Moreover, these receptors favor a bidirectional interaction with T-suppressor and T-regulator cells, generating an antigen-specific immunoregulator cascade, in which the dendritic cell behaves as a tolerogenic cell. In the current review, analysis is centered on the biology and behavior of the tolerogenic dendritic cells that express high levels of ILT3 and ILT4. Some molecular and genetics aspects of these receptors are discussed as well as their importance in the modulation of the allo-specific antigen immune response to transplants

Keywords : Transplantation; dendritic cells; immune tolerance; immunomodulation; survival.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License