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Biomédica

Print version ISSN 0120-4157

Abstract

DE MELO BEZERRA, Laiane Fernanda et al. Serological evidence of leptospirosis in patients with a clinical suspicion of dengue in the State of Ceará, Brazil. Biomédica [online]. 2015, vol.35, n.4, pp.557-562. ISSN 0120-4157.  http://dx.doi.org/10.7705/biomedica.v35i4.2504.

Introduction: Dengue and leptospirosis are two febrile illnesses of great clinical and epidemiological importance in Brazil. Their significant degree of symptomatic similarity makes clinical diagnosis difficult. Objective: To diagnose leptospirosis differentially in patients with clinically suspected dengue. Materials and methods: In this study, 86 patients with clinically suspected dengue underwent virological and serological diagnostic evaluations for dengue (reverse transcriptase polymerase chain reaction, NS1 immunochromatographic test, and NS1 enzyme-linked immunosorbent assay, ELISA), as well as tests to detect immunoglobulin M (IgM; IgM/IgG Rapid Test and IgM ELISA). The same patients were subsequently evaluated for leptospirosis using Rapid Test IgG/IgM (Bioeasy ® ) and Leptospira IgM ELISA (PanBio ® ). Results: Of the 86 patients, 48 (55.8%) had positive results for dengue in at least one of the tests and five (7.35%) showed positive reactions for leptospirosis. Conclusion: During dengue epidemics, this disease may be misdiagnosed as other infections, including leptospirosis, when diagnosis is based on nonspecific clinical and laboratory criteria alone.

Keywords : Leptospirosis; dengue; differential diagnosis; reverse transcriptase polymerase chain reaction; enzyme-linked immunosorbent assay.

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