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Biomédica

versión impresa ISSN 0120-4157

Resumen

LLERENA, Claudia; ZABALETA, Angie; VALBUENA, Angélica  y  MURCIA, Martha. Prevalence of Mycobacterium tuberculosis resistance to quinolones and injectables in Colombia, 2012-2013. Biomédica [online]. 2017, vol.37, n.1, pp.96-103. ISSN 0120-4157.  http://dx.doi.org/10.7705/biomedica.v37i2.3204.

Introduction:

Tuberculosis is a health problem worldwide. The World Health Organization estimated 9.6 million new cases and 480,000 multirresistant cases for 2014. The assessment of resistance to quinolones and injectables was implemented only a few years ago, so its prevalence is not known.

Objective:

To determine the prevalence of resistance to amikacin, capreomycin and ofloxacin in cases of tuberculosis resistant to isoniazid and/or rifampin during 2012-2013.

Materials and methods:

This was a cross-sectional study of 489 isolates resistant to isoniazid and/or rifampin. We used the Bactec MGITTM technique for susceptibility tests. For analyzing the rate of resistance, we grouped cases according to the history of treatment with second line drugs.

Results:

In the 438 new cases, the drug that showed greater overall resistance was kanamycin with 7.1 % (95% CI: 4.6 to 9.6). In 51 previously treated cases, this highest resistance was 27.5 % (95% CI: 14.2 to 40.7). The overall resistance was higher in cases with a history of treatment with quinolones and injectables. We found seven cases of extremely resistant tuberculosis.

Conclusion:

This study demonstrates the presence of resistance to second line drugs in people with drug-resistant tuberculosis with and without previous treatment with quinolones and/or injectables, these latter having a higher percentage of resistance. For that reason, it is essential to perform susceptibility testing and analyze this information routinely.

Palabras clave : Mycobacterium tuberculosis; tuberculosis, multidrug-resistant; MDR tuberculosis; extensively drug-resistant tuberculosis; isoniazid; rifampin; Colombia.

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