SciELO - Scientific Electronic Library Online

 
vol.37 issue3Socioeconomic status, eating patterns, and heavy metals exposure in women of childbearing age in Cali, ColombiaProfiles of intestinal polyparasitism in a community of the Colombian Amazon region author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Article

Indicators

Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google

Share


Biomédica

Print version ISSN 0120-4157

Abstract

BELTRAN, Mauricio et al. Detection of Trypanosoma cruzi antibodies in multitransfused patients in Colombia. Biomédica [online]. 2017, vol.37, n.3, pp.361-367. ISSN 0120-4157.  http://dx.doi.org/10.7705/biomedica.v34i2.3177.

Introduction:

Chagas disease is a public health problem in Latin America. Even though vector-borne infection is the most important transmission mode for this disease, other modes such as transfusions require evaluation.

Objective:

To describe the prevalence of T. cruzi infection in multitransfused patients.

Materials and methods:

We detected IgG antibodies against T. cruzi by two immunoassays in samples from multitransfused patients in four hospitals located in Bogotá and Medellín, Colombia. We analyzed the association with known risk factors, and we calculated the odds ratios (OR) with 95% confidence intervals using Stata 11(tm) statistical software.

Results:

In total, 479 samples were tested. Overall, T. cruzi antibody prevalence was 1.88% (nine patients). Five were onco-hematological patients, two were hemodialyzed, one had thalassemia, and one had suffered acute blood loss. We found no hemophilia patients. There was no association between known risk factors for transfusion-transmitted infection (such as the number of transfusion events, number of blood units and type of blood component) and the presence of anti-T. cruzi antibodies in this study. Only the hepatitis C virus infection showed a positive association with the presence of anti-T. cruzi antibodies (OR=5.68, 95% CI: 1.36-23.63).

Conclusions:

The results of this study showed a low frequency of T. cruzi infection in multitransfused patients, suggesting that the risk of transfusion infection in Colombia is low. Known risk factors for transfusion-related infection were not associated with the presence of anti-T. cruzi antibodies.

Keywords : cruzi; blood transfusion; prevalence; risk factors; antibodies; hemophilia A.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )