SciELO - Scientific Electronic Library Online

vol.37 número4Wernicke-Korsakoff syndrome secondary to cytomegalovirus encephalitis: A case reportOptimizing resources to reduce costs to determine HIV viral load in limited resources settings índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados



Links relacionados

  • Em processo de indexaçãoCitado por Google
  • Não possue artigos similaresSimilares em SciELO
  • Em processo de indexaçãoSimilares em Google



versão impressa ISSN 0120-4157


SAN JUAN, Javier L. et al. In vitro susceptibility of Cuban Aspergillus spp. strains of clinical and environmental origin. Biomédica [online]. 2017, vol.37, n.4, pp.452-459. ISSN 0120-4157.


The behavior of antifungal susceptibility of Aspergillus spp. in Cuba remains unknown. The antifungals recommended to treat aspergillosis are amphotericin B, itraconazole, voriconazole and echinocandins. The influence of the environment may set off the emergence of drug-resistance in these microorganisms.


To evaluate in vitro susceptibility of Aspergillus spp. strains to amphotericin B, itraconazole and voriconazol, and the relationship between susceptibility patterns and their origin.

Materials and methods:

Minimum inhibitory concentrations of amphotericin B, itraconazole and voriconazole were determined for 60 Aspergillus spp. strains of clinical and environmental origin using the M38-A2 method of the Clinical and Laboratory Standards Institute.


We found 21 amphotericin B resistant strains (mainly from clinical samples and hospital environments), as well as three itraconazole resistant strains (from non-hospital outdoor and indoor environments). No voriconazole resistance was found. No relationship was found between strain origin and susceptibility.


Results suggest the possible existence of environmental factors or interactions with resistant genotypes which may give rise to resistant phenotypes in our country. This is the first report of in vitro Aspergillus spp. resistant strains in Cuba. These studies should be broadened and include molecular and phylogenetic analyses.

Palavras-chave : Aspergillus; drug resistance, fungal; amphotericin B; itraconazole; voriconazole.

        · resumo em Espanhol     · texto em Espanhol     · Espanhol ( pdf )