SciELO - Scientific Electronic Library Online

 
vol.38 número3Caracterización de las potenciales interacciones farmacológicas en pacientes de una unidad de cuidados intensivos en un hospital de tercer nivel de BogotáNiveles séricos de adipocitocinas y resistencia a la insulina en el primer trimestre de gestación en adolescentes y su relación con el peso del recién nacido índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

Links relacionados

  • En proceso de indezaciónCitado por Google
  • No hay articulos similaresSimilares en SciELO
  • En proceso de indezaciónSimilares en Google

Compartir


Biomédica

versión impresa ISSN 0120-4157

Resumen

MACHADO-ALBA, Jorge Enrique; CALVO-TORRES, Luis Felipe; GAVIRIA-MENDOZA, Andrés  y  CASTRILLON-SPITIA, Juan Daniel. Prescribing patterns of antiparkinson drugs in a group of Colombian patients, 2015. Biomédica [online]. 2018, vol.38, n.3, pp.417-426. ISSN 0120-4157.  https://doi.org/10.7705/biomedica.v38i4.3781.

Introduction:

Parkinson’s disease, whose prevalence in Colombia is 4.7 per 1,000 inhabitants, is a public health problem and a therapeutic challenge for health professionals.

Objective:

To determine the prescribing patterns of antiparkinson drugs and the variables associated with its use in a population from Colombia.

Materials and methods:

We conducted a descriptive cross-sectional study. We selected patients who had been given antiparkinson drugs uninterruptedly between January 1st and March 31st, 2015 from a systematized database of approximately 3.5 million people affiliated to the Colombian health system.

We included sociodemographic, pharmacologic and comedication variables. For the multivariate analysis, we used the IBM SPSS™-22 software.

Results:

A total of 2,898 patients was included; the mean age was 65.1years, and 50.7% were men; 69.4% (n=2010) of people received monotherapy and 30.6% combination therapy with two to five antiparkinson drugs. The most frequently prescribed drugs were: levodopa 45.5% (n=1,318 patients), biperiden 23.1% (670), amantadine 18.3% (531) and pramipexole 16.3% (471). The most commonly used association was levodopa/carbidopa + entacapone (n=311; 10.7%). Multivariate analysis showed that being male (OR=1.56; 95%CI: 1.321-1.837), over 60 years (OR=1.41; 95%CI 1.112-1.782) and receiving treatment in the city of Barranquilla (OR=2.23; 95%CI 1.675-2.975) were statistically associated with a greater risk of using combination therapy; 68.2% (n=1,977) patients were given concomitant treatment with other drugs.

Conclusions:

Prescribing habits of drugs with high therapeutic value predominated, mainly in antiparkinson drugs monotherapy. Most were employed in the usual recommended doses. It is necessary to explore the clinical effectiveness of the medications studied and differentiate between disease and parkinsonian syndromes subtypes.

Palabras clave : Parkinson disease; antiparkinson agents; pharmacoepidemiology; drug prescriptions; drug utilization; Colombia.

        · resumen en Español     · texto en Inglés     · Inglés ( pdf )