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Biomédica
versão impressa ISSN 0120-4157
Resumo
MACHADO-ALBA, Jorge E.; ATEHORTUA-OTERO, Miguel A. e CORTES-MEJIA, Diego A.. Profile of antiretroviral agents use in Colombia. Biomédica [online]. 2018, vol.38, n.4, pp.527-533. ISSN 0120-4157. https://doi.org/10.7705/biomedica.v38i4.388.
Introduction:
Since the beginning of the epidemic, human immunodeficiency virus (HIV) has taken more than 36 million lives.
Objective:
To determine the antiretroviral drug prescription patterns in a population of individuals with HIV infection in Colombia.
Materials and methods:
Cross-sectional study analyzing the profiles of patients treated with antiretroviral drugs between April 1st and September 30th, 2015. The sociodemographic, pharmacological, and comorbidity variables were identified. Individuals with a positive diagnosis of HIV of all ages and both genders were included.
Results:
We found 641 patients with a mean age of 39.0±17 years who were predominantly male (60.2%). The most used medications were lamivudine-zidovudine (51.6%), lopinavir-ritonavir (36%) and efavirenz (24.5%). The combination of lamivudine-zidovudine plus lopinavir-ritonavir was the most prescribed regimen (29.5%), but a total of 80 different regimens was identified. Being an adult between the ages of 45-64 years (OR=2.25; 95%CI 1.367-3.713) was associated with a greater probability of receiving 4 or more antiretrovirals. A total of 267 (41.6%) patients used at least one comedication (range: 1-18 drugs), especially anti-ulcer (57.3%), lipid-lowering (28.8%) and anti-hypertensive (28.5%) drugs.
Conclusions:
Patients undergoing antiretroviral treatment are receiving medications with elevated intrinsic values at the recommended doses and present comorbidities associated with chronic agerelated conditions. However, these patients receive a great variety of regimens that are not included in the clinical practice guidelines.
Palavras-chave : Acquired immunodeficiency syndrome; antiretroviral therapy, highly active; drug prescriptions; pharmacoepidemiology.