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Print version ISSN 0120-4157


CAMPO, César Hernán; MARTINEZ, María Fernanda; OTERO, Juan Carlos  and  RINCON, Giovanna. Vagino-rectal colonization prevalence by Streptococcus agalactiae and its susceptibility profile in pregnant women attending a third-level hospital. Biomédica [online]. 2019, vol.39, n.4, pp.689-698.  Epub Dec 30, 2019. ISSN 0120-4157.


Streptococcus agalactiae is the main etiological agent causing invasive infection of the newborn with symptoms that may be associated with septicemia, pneumonia or meningitis and prevalences up to 50% worldwide where there is an increase in antibiotic resistance.


To estimate the prevalence of vagino-rectal colonization by S. agalactiae and its sensitivity profile in pregnant women attending a third-level hospital.

Materials and methods:

One hundred and twenty one pregnant women were sampled by vaginal and rectal swabs. The cultures were carried out following the methodology recommended by the CDC, and chromID Strepto B agar was added. The suggestive colonies were identified biochemically and the sensitivity profiles according to CLSI were determined. As control, S. pneumoniae ATCC 49619 and S. agalactiae ATCC 12403 were used.


Pregnant colonization prevalence by S. agalactiae was 20.66%, with a total of 40 isolates of which 12.5% were non-sensitivity to penicillin. Sensitivity to levofloxacin, clindamycin and erythromycin was 100%, 92.5% y 87.5%, respectively, with the phenotypes iMLSB (3/40) and M (2/40). No sensitivity to tetracycline was found.


The prevalence of vagino-rectal colonization by S. agalactiae in the study population was 20.66%, obtaining isolates not sensitive to penicillin and resistance to macrolides and lincosamidas by the Kirby-Bauer technique, so the importance of carrying out active active in pregnant women colonized by Streptococcus agalactiae and to perform constant epidemiological surveillance to detect changes in the sensitivity profiles of the isolates.

Keywords : Streptococcus agalactiae; pregnant women; neonatal sepsis; prophylaxis antibiotic.

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