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Biomédica
versão impressa ISSN 0120-4157
Resumo
ONATE-GUTIERREZ, José Millán et al. Clostridium difficile infection: Description of NAP1/027 and non NAP1/027 strains in a high complexity center in Cali, Colombia, 2012-2015. Biomédica [online]. 2019, vol.39, suppl.1, pp.63-70. ISSN 0120-4157. https://doi.org/10.7705/biomedica.v39i2.3950.
Introduction:
Clostridium difficile causes nosocomial infections leading to high morbidity and mortality. The NAP1/027 strain is associated with a higher toxin production and disease severity, which increases the load of the disease.
Objective:
To describe the epidemiology of the infections associated with C. difficile and the characteristics related to the NAP1/027 strain.
Materials and methods:
This was an observational study based on the revision of clinical registries of patients with fecal samples that were positive for C. difficile identified by the Xpert test™ between 2012 and 2015 in a high complexity institution. The severity of the disease was evaluated by means of the ATLAS score.
Results:
We included 42 infected cases, 9 of which were positive for the NAP1/027strain. The use of antibiotics previous to the infection for more than seven days was more frequent in patients with negative results for NAP1/027. The duration of diarrhea in half of the patients was longer than five days and there were no differences according to the type of strain (p>0.05). Positive cases for the NAP1/027 strain were characterized by presenting fetid and bloody stools. The severity of the infection was similar between the groups.
Conclusions:
In Colombia, the NAP1/027 strain circulates without significant clinical differences, which could be due to the limited number of patients. Nevertheless, the existence of NAP1/027 should alert physicians and health institutions because of its high association with severity and mortality.
Palavras-chave : Clostridium difficile; diarrhea; anti-bacterial agents; bacterial infections/ epidemiology; enterocolitis, pseudomembranous.