SciELO - Scientific Electronic Library Online

 
vol.39 suppl.1Importance of investigating Mycobacterium bovis in clinical samples of human originDetection of multidrug-resistant Enterobacteriaceae isolated from river waters flowing to the Guanabara Bay and from clinical samples of hospitals in Rio de Janeiro, Brazil índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Journal

Artigo

Indicadores

Links relacionados

  • Em processo de indexaçãoCitado por Google
  • Não possue artigos similaresSimilares em SciELO
  • Em processo de indexaçãoSimilares em Google

Compartilhar


Biomédica

versão impressa ISSN 0120-4157

Resumo

AREVALO, Azucena; OTERO, William  e  TRESPALACIOS, Alba Alicia. Helicobacter pylori: Multiple resistance in patients from Bogotá, Colombia. Biomédica [online]. 2019, vol.39, suppl.1, pp.125-134. ISSN 0120-4157.  https://doi.org/10.7705/biomedica.v39i3.4437.

Introduction:

The main cause for Helicobacter pylori infection treatment failure is antibiotic resistance, where clarithromycin and metronidazole play the main role. In Colombia, primary resistance as a consequence of the use of these two antibiotics and excessive levofloxacin use is above the accepted limit (13.6%, 83%, and 16%, respectively). Despite this fact, empirical therapies that include the combination of these antibiotics are used in patients with previous therapeutic failure.

Objective:

To determine antibiotic resistance in patients previously treated for H. pylori in Bogotá, Colombia.

Materials and methods:

We conducted a descriptive study that included ten isolates obtained from five patients with three or four previous failed treatments for H. pylori. Antibiotic resistance to amoxicillin, clarithromycin, levofloxacin, and metronidazole was investigated by agar dilution and confirmed by DNA sequencing (Magrogen, Korea).

Results:

Eight isolates were resistant to two or more antibiotics. All isolates were resistant to levofloxacin. Susceptibility patterns in isolates from the gastric antrum and the body of the stomach were different in three patients.

Conclusion:

As far as we know, this is the first evidence of multiple H. pylori resistance in Colombia in previously treated patients. Results demonstrated the consequences of using an ineffective antibiotic scheme and the need to assess antibiotic susceptibility in different anatomical sites of the stomach. The consequences of multiple resistance decrease possible antibiotic effectiveness to eradicate H. pylori in the future.

Palavras-chave : Helicobacter pylori; drug resistance, multiple; anti-bacterial agents; susceptibility test; mutation; therapy.

        · resumo em Espanhol     · texto em Espanhol     · Espanhol ( pdf )