SciELO - Scientific Electronic Library Online

 
vol.39 suppl.1Francisco Campos-Rivadeneira and Roberto Levi- Castillo: Their lives and contributions to the study of mosquitoes (Diptera: Culicidae) in Ecuador índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Journal

Artigo

Indicadores

Links relacionados

  • Em processo de indexaçãoCitado por Google
  • Não possue artigos similaresSimilares em SciELO
  • Em processo de indexaçãoSimilares em Google

Compartilhar


Biomédica

versão impressa ISSN 0120-4157

Resumo

RADA, Ana Mercedes; HERNANDEZ-GOMEZ, Christian; RESTREPO, Eliana  e  VILLEGAS, María Virginia. Distribution and molecular characterization of beta-lactamases in Gram-negative bacteria in Colombia, 2001-2016. Biomédica [online]. 2019, vol.39, suppl.1, pp.199-220. ISSN 0120-4157.  https://doi.org/10.7705/biomedica.v39i3.4351.

Beta-lactamases are enzymes with hydrolytic activity over beta-lactam antibiotics and they are the main resistance mechanism in Gram-negative bacteria. Extended-spectrum beta-lactamases (ESBL), AmpC, and carbapenemases have the greatest clinical and epidemiological impact in hospital settings. The increasing frequency and worldwide spread of these enzymes have limited the therapeutic options in hospital-acquired infections and those originating in the community.

In Colombia, surveillance networks and research groups began studying them in the late 90s. Different variants of these enzymes have been molecularly characterized and their high prevalence and dissemination in medium and high complexity hospitals, along with a high clinical impact, have been reported. Furthermore, many studies in Colombia have evidenced high endemicity for some of these beta-lactamases, which requires an urgent implementation of antimicrobial stewardship programs in order to preserve the few therapeutic options and infection control strategies to prevent and limit their dissemination.

In this publication, we carried out a review of the different enzyme variants, geographic distribution, and molecular characterization of these beta-lactamases in Colombia. Additionally, we describe the available information in the literature regarding studies conducted between the late 1990s and 2016, which provide an overview of the beta-lactamases circulating in different regions of Colombia, their increase over time, and their clinical implications.

Palavras-chave : Beta-lactamases; Gram-negative bacteria; bacterial infections; antimicrobial stewardship; Colombia.

        · resumo em Espanhol     · texto em Espanhol     · Espanhol ( pdf )