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Biomédica
versão impressa ISSN 0120-4157versão On-line ISSN 2590-7379
Resumo
RASHIDI, Farzad e OSTADSHARIF, Maryam. Association of VDR gene Apal polymorphism with obesity in Iranian population. Biomed. [online]. 2021, vol.41, n.4, pp.651-659. Epub 15-Dez-2021. ISSN 0120-4157. https://doi.org/10.7705/biomedica.5898.
Introduction:
Identifying obesity risk factors as a health problem facing communities is crucial given its complexity. The vitamin D receptor gene has been reported as a possible cause of this disease.
Objective:
To study the association of the VDR gene ApaI, BsmI, and TaqI polymorphisms with obesity in an Iranian population.
Material and methods:
We analyzed the genotypes of 348 obese (BMI≥30 kg/m2) and 320 non-obese people (BMI: 18.5-24.9 kg/m2) using PCR-RFLP. We measured FBS, TG, total cholesterol, and HDL and LDL cholesterol levels in an automatic biochemical analyzer.
Results:
We found significantly higher BMI, FBS, and TG levels in the obese group compared to the control. In the obese individuals, the frequency of genotype AA was 47.1% and that of the combined Aa+aa genotype, 52.9% while in the control group they were 30% and 70%, respectively (p=0.024, 95% confidence interval (CI)=1.100-3.933, odds ratio (OR)=2.08). A and a alleles frequencies for the ApaI polymorphism were statistically significant in the two groups (allele A vs. a; p=0.017). No significant relationship was observed between TaqI genotypes and alleles in the control and obese subjects.
Conclusion:
We found that VDR ApaI (rs7975232 C/A) polymorphism appeared to be a risk factor for obesity. Especially, the A allele and the AA genotype in ApaI were associated with the obesity phenotypes.
Palavras-chave : Obesity/genetic; vitamin D; polymorphism, genetic; body mass index; Iran.