Abstract

RIVERA, Jorge et al. Inmunohistochemical detection of pandemic SARS-CoV-2 antigens in lung tissue. Biomed. [online]. 2022, vol.42, suppl.2, pp.9-13.  Epub Oct 31, 2022. ISSN 0120-4157.  https://doi.org/10.7705/biomedica.6132.

The COVID-19 pandemic caused by the SARS-CoV-2 virus has generated globally more than 110.7 million infections and 2.4 million deaths. The severity of this infection can range from asymptomatic, mild to severe.

To know the possible associations between the presence of the virus and histopathological alterations found in tissues of fatal cases of COVID-19, the presence of the virus in the lung tissue of a patient with a clinical history of SARS-CoV-2 infection was evaluated.

Lung tissue was histologically processed for immunohistochemical detection of SARS- CoV-2. In the histopathological study, morphological changes associated with pneumonitis of viral origin were observed. Likewise, the location of the SARS-CoV-2 virus was observed mainly in the cytoplasm of the cells of the inflammatory infiltrate.

Keywords : COVID-19; lung; immunohistochemistry; antigens, viral.

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