Resumo

RUIZ SAENZ, JULIÁN  e  URCUQUIINCHIMA, SILVIO. Equine Herpesvirus Replication and It’s Association with Molecular Pathogenesis. Acta biol.Colomb. [online]. 2006, vol.11, n.2, pp.3-20. ISSN 0120-548X.

Equine herpesvirus (EHV) is one of the most important viral pathogens in worldwide equine industry, due to the dramatic economic looses incurred by these microorganisms. The clinical disease, commonly called equine rhinopneumonitis, is characterized by initial infection of the upper respiratory tract that progresses through the mucosa; it can cause abortion in the last months of gestation, stillbirth, perinatal death of foals and myeloencephalitis. Productive infection is followed by a state of viral latency during which the animal presents no clinical symptoms and there is no viral replication. During a stress situation, the virus in the infected horses is reactivated and can infect healthy horses. This review presents in a synthetic manner, the main findings related with the study of viral replication and molecular pathogenesis of EHV; it also presents the main findings related to proteins involved in the regulation of viral genome replication, all the structural glycoproteins that have been studied to date and that constitute the central axis of different research centres around the world. In addition, it discusses the true importance of direct celltocell dispersion of the virus, the formation of plaques, in vitro growth, and in some cases association with the pathogenesis either in an animal model or in the natural host.

Palavras-chave : EHV; genome; glycoprotein; ORF; replication.

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