Resumo

RUIZ, JULIÁN; JAIME, JAIRO  e  VERA, VÍCTOR. Bovine Herpesvirus-1: The Role of Latency-Related Genes. Acta biol.Colomb. [online]. 2008, vol.13, n.1, pp.3-22. ISSN 0120-548X.

Bovine herpesvirus-1 is a world wide spread virus that causes significant economic losses due mainly to a decrease in the efficiency and in the health and productivity indicators in all the infected herds. After a primary infection of the respiratory tract of the animals, the virus establishes viral latency state in sensory neurons of trigeminal ganglia and germinal centers of pharyngeal tonsils. Periodically, the virus reactivates from latency, is shed through secretions, and can infect other susceptible animals. During latency there is a dramatic reduction of viral gen expression; only two transcripts are abundantly expressed: the latency related (LR) RNA and the viral ORF-E. Multiple studies have shown LR and ORF-E role in the regulation of BHV-1 latencyreactivation cycle. This review focuses on the description and analysis of the litherature that had lead to incriminate LR gene and viral ORF-E, their transcripts and protein products in the establishment, maintenance and reactivation of BHV-1 latency state.

Palavras-chave : Herpesvirus; Latency; transcripts; ORF.

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