Acta Biológica Colombiana
versão impressa ISSN 0120-548X
LOPEZ, MARY LUZ e SEGURA LATORRE, CESAR. The New Permeability Pathways And Cytosolic pH: Targets For Antimalarial Agents On Plasmodium falciparum. Acta biol.Colomb. [online]. 2008, vol.13, n.2, pp. 3-22. ISSN 0120-548X.
In malaria, attention has been posed to search or develop new antimalarial drugs or their modifications against different therapeutic targets in P. falciparum. Therapeutic targets such physiological parameters and solute transport have been proposed to kill the parasite and they represent an option for development of new drugs. We present a review on the effects of steroids, in particular the antiplasmodial steroids isolated from Solanum nudum, stressing two physiological Plasmodium processes such as the new permeability pathways on the infected red blood cells and the cytosolic pH regulation.
Palavras-chave : Plasmodium falciparum; antimalarial drugs; biological membranes; cytosolic pH.