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Acta Biológica Colombiana

Print version ISSN 0120-548X


RUIZ-SAENZ, JULIÁN; JAIME, JAIRO  and  VERA, VÍCTOR. Bovine Herpesvirus-1 Vaccine’s: A Look From The Past To The Immunization Future. Acta biol.Colomb. [online]. 2009, vol.14, n.2, pp.3-20. ISSN 0120-548X.

Bovine herpesvirus-1 is one of the most important pathogens of cattle; the primary infection is characterized by clinical manifestations such as infectious bovine rhinotracheitis, abortion, infectious pustular vulvovaginitis and in some cases, neurological signs. After recovering, the virus establishes viral latency in sensory neurons of trigeminal or sacral ganglia. The World Organization for Animal Health (OIE) reports that vaccination against BHV-1 could be useful to reduce the clinical manifestations and in consequence the economic looses, but it can not protect against the infection. Therefore, a huge amount of vaccines have been developed that includes from classic inactivation to recombinant DNA technologies. This paper makes an updated review about the most used vaccines since many years and try to resume the most important advances in BHV-1 vaccine’;s generation; trying to open a window for new vaccine’;s generation in Colombia.

Keywords : Bovine herpesvirus; vaccine; immune; recombinant.

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