Abstract

LAMPREA, N; GUERRERO, M; MUNERA, A  and  LAMPREA, M. Interaction Between Hygrophila tyttha Extract and Scopolamine in a Episodic Memory Test in Rats. Acta biol.Colomb. [online]. 2009, vol.14, n.2, pp.41-48. ISSN 0120-548X.

The main objective of this study was to evaluate the interaction between the concentrated ethanolic extract of Hygrophila tyttha (500 mg/kg, per os) and the cholinergic antagonist scopolamine (0.3 mg/kg, intraperitoneal) in an animal model of episodic memory. The extract was obtained by percolation from fresh vegetal material and was administered 30 minutes before scopolamine. Thirty minutes after the scopolamine the subjects were trained in a spatial context recognition task. One hour after the training the exploration of both the open field and the objects. The results showed that scopolamine administration, associated or not to Hygrophila tyttha extract, impaired both spatial context recognition and open field habituation but did not affect object exploration. The only effect of Hygrophila tyttha extract and scopolamine joint administration was a significant increase in open field exploratory behavior. Such results suggest that Hygrophila tyttha extract did not have significant interactions with scopolamine amnesic effect, while it did potentiate the exploratory behavior stimulant effect of scopolamine.

Keywords : Hygrophila tyttha extract; scopolamine; eisodic memory; rats.

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