Acta Biológica Colombiana
Print version ISSN 0120-548X
The nuclear pore complex (NPC) is a large supramolecular assemble made up of multiple copies of about 30 different families proteins, so in total 456 nucleoporines (Nups) span the nuclear envelope of all Eukariotic organisms. The NPC is considered the gate through which all macromolecules must pass in order to achieve nucleo-cytoplasmic transport. The aim of this review is to describe the structure, mechanisms and processes involved during the transportation of molecules and how of these processes are regulated by highly dynamic macromolecular interactions with molecules of the NPC which have been described during the past years.
Keywords : Nuclear pore complex (CPN); macromolecular transport; nucleoproteins (Nups).