Acta Biológica Colombiana
Print version ISSN 0120-548X
DIAZ, GLORIA et al. AUTOMATIC CLASSIFICATION OF STRUCTURAL MRI FOR DIAGNOSIS OF NEURODEGENERATIVE DISEASES. Acta biol.Colomb. [online]. 2010, vol.15, n.3, pp. 165-180. ISSN 0120-548X.
This paper presents an automatic approach which classifies structural Magnetic Resonance images into pathological or healthy controls. A classification model was trained to find the boundaries that allow to separate the study groups. The method uses the deformation values from a set of regions, automatically identified as relevant, in a process that selects the statistically significant regions of a t-test under the restriction that this significance must be spatially coherent within a neighborhood of 5 voxels. The proposed method was assessed to distinguish healthy controls from schizophrenia patients. Classification results showed accuracy between 74% and 89%, depending on the stage of the disease and number of training samples.
Keywords : Neurodegenerative disease; structural MRI; pattern classification; SPM; VBM; DARTEL; support vector machines.