Acta Biológica Colombiana
Print version ISSN 0120-548X
CABEZAS-PEREZ, RICARDO et al. IGF-II and Chorionic Gonadotropin Regulate Proliferation, Migration and Invasion of Human Trophoblast Cells. Acta biol.Colomb. [online]. 2011, vol.16, n.1, pp. 143-152. ISSN 0120-548X.
Both IGF-II and chorionic gonadotropin (hCG) are important regulators of human trophoblast migration and implantation; however the molecular mechanisms are not fully understood. The purpose of this study was to determine the potential cross-talk between functional effects of hCG and IGF-II in the regulation of trophoblast proliferation, migration and invasion. Using the HTR-8/SVneo trophobast cell line we found that IGF-II stimulates cell proliferation and, for the first time we demonstrate that hCG at high doses is able to promote trophoblast proliferation through a mechanism independent of IGF-II. In contrast, trophoblast invasiveness was regulated by both IGF-II and hCG and an additive effect between the two hormones was observed. In conclusion, our results demonstrate cross-talk between the biological activities of IGF-II and hCG in the regulation of trophoblast invasiveness and contribute to a better understanding of the trophoblast biology and pathology.
Keywords : trophoblast; invasion; migration; IGF-II; hCG.