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Acta Biológica Colombiana

Print version ISSN 0120-548X

Abstract

F. LUCENA, Bruno F et al. Evaluation of Antibacterial Activity of Aminoglycosides and Modulating the Essential Oil of Cymbopogon citratus (DC.) Stapf. Acta biol.Colomb. [online]. 2015, vol.20, n.1, pp.39-45. ISSN 0120-548X.  http://dx.doi.org/10.15446/abc.v20n1.41673.

Several works demonstrated the importance of the study of natural products as an alternative source for new antimicrobial drugs or for modulators for these ones. In this point, the aim of this was to investigate the antibacterial activity and the possible interactions between the essential oil of Cymbopogon citratus alone and in association with aminoglycosides against standard and clinically isolated strains of multidrug-resistant bacteria such as S. aureus, E. coli and P. aeruginosa by microdilution method. The results indicated a synergism between the antibiotics and the essential oil with a subinhibitory concentration (MIC/8), reducing the minimal inhibitory concentration (MIC) sixteen times against the multidrug-resistant strains of S. aureus 358, E. coli 27 and P. aeruginosa 143, but none modulatory activity was observed against P. aeruginosa 78 and P. aeruginosa 91 strains. By our results, can be concluded that the essential oil of Cymbopogon citratus can be an interesting source of natural products with antibacterial and/or modulatory antibiotic activities.

Keywords : Cymbopogon citratus; Escherichia coli; essential oil; Pseudomonas aeruginosa; Staphylococcus aureus.

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