Abstract

TINTINO, Saulo R et al. Antimicrobial Activity and Combined Effects on Antifungal and Antibacterial Drugs the Fruit of Morinda citrifolia L.. Acta biol.Colomb. [online]. 2015, vol.20, n.3, pp.193-200. ISSN 0120-548X.  https://doi.org/10.15446/abc.v20n3.45601.

The rising of the drug resistant microrganisms and the toxicity related with the antimicrobial drugs enhances the necessity about the search of new bioactive compounds. Morinda citrifolia L. is a fruit tree traditionally used as antibacterial and with several other pharmacological properties. This plant presents several phytocompounds as flavonoids, alkaloids and triterpenes. The objective of this work was assay the antimicrobial and modulatory potential of the fruit extract. The extract was assayed alone and associated with antibiotics and antifungals against pathogenic microrganisms using the microdilution assay. The results demonstrated that the association between extract and antimicrobial drugs resulted in a potentiation of the drug activity clinically relevant against Pseudomonas aeruginosa and Escherichia coli.

Keywords : extracts; modulatory effect; secondary metabolites; multidrug-resistant.

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