Abstract

MEZA LASSO, Daniel Mauricio et al. Expression of Serrate1 and Notch1 Genes During Chicken Embryo Midface Development. Acta biol.Colomb. [online]. 2016, vol.21, n.1, pp.175-182. ISSN 0120-548X.  https://doi.org/10.15446/abc.v21n1.49336.

The Notch signaling pathway is characterized by mediate cell-cell communication, regulating different cellular processes as proliferation, apoptosis and cell fate definition. This pathway has been implicated in craniofacial structures development as palate, teeth and cranial vault. The objective of this research was to identify the genes expression patterns of some Notch signaling pathway components, Serrate1 and Notch1, during the midface development. It was used chicken embryos (Callus gallus) selected according to Hamilton and Hamburger criteria. We performed in situ hybridization with Digoxigenin (DIG)-labeled riboprobes and detected with the antibody Anti-Dig. The results showed the expression of the evaluated genes in the maxillary (pmx) and frontonasal (pfn) prominences during the midface development. These results suggest a probable involvement of the Notch pathway through these genes in different cellular processes that determine midface morphogenesis and development.

Keywords : Facial development; frontonasal prominence; maxillary prominences; Notch signaling pathway; Notch1; Serrate1.

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