SciELO - Scientific Electronic Library Online

 
vol.23 número2New Species of Water Striders (Hemiptera: Heteroptera: Gerridae) from ColombiaIdentification of a Microalgae Collection Isolated from Costa Rica by 18S rDNA Sequencing índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Artigo

Indicadores

Links relacionados

  • Em processo de indexaçãoCitado por Google
  • Não possue artigos similaresSimilares em SciELO
  • Em processo de indexaçãoSimilares em Google

Compartilhar


Acta Biológica Colombiana

versão impressa ISSN 0120-548X

Resumo

VELANDIA, Sindi Alejandra; QUINTERO, Elizabeth; STASHENKO, Elena E  e  OCAZIONEZ, Raquel E. Antiproliferative Activity of Essential Oils from Colombian Plants. Acta biol.Colomb. [online]. 2018, vol.23, n.2, pp.189-198. ISSN 0120-548X.  http://dx.doi.org/10.15446/abc.v23n2.67394.

Colombia has a great diversity of medicinal plants, but few have been investigated. In this work, the antiproliferative activity of essential oils obtained by microwave-assisted hydrodistillation was evaluated. Fifteen samples from 11 species were analyzed in MTT assays in cancer cells MCF-7, HeLa and HepG-2, and normal human cells (HEK293) and animal cells (Vero and B16F10) were included to evaluate selectivity. The chemical composition of the active oils was determined by gas chromatography coupled to mass spectrometry (GC-MS). Essential oils from four species showed antiproliferative activity (IC50: <50 μg / mL) in HeLa and / or MCF-7 cells, in the following range (selectivity index in parenthesis): Piper cumanense H.B.K. (4.7) > Piper subflavum var. espejuelanum C. DC (3.9) > Salvia officinalis Linneo. (3.6) > Piper eriopodom (Miq.) C.DC. (31). The CG-MS analysis identified β-caryophyllene, a-copaene, β-pinene, a-pinene and linalool as major components. Active essential oils could serve as starting points to develop herbal medicines for cancer palliative care.

Palavras-chave : essential oil; apoptosis; cancer; MTT; phytotherapy.

        · resumo em Espanhol     · texto em Espanhol     · Espanhol ( pdf )