Resumo

MENDOZA MEZA, Dary Luz; LOZANO SOCARRAS, Sonja; JAIMES SANABRIA, María Belén  e  EGEA, Eduardo. Association between atopy, allergic asthma and specific IgE antibodies for Ascaris in a group of children of a city of the north coast of Colombia. Salud, Barranquilla [online]. 2008, vol.24, n.2, pp.172-180. ISSN 0120-5552.

Introduction: Asthma is a disease widely distributed in the world, with more than 400 million people affected. Actuality exist a great interest to determine the possible protective effect of geohelminthiasis in the asthma. Objetive: In order to establish the relationship between Áscaris (AS) and Dermatophoides pteronyssinus (Dpt) mites sensitization with the classification of the bronchial asthma severity an analytical study of cases and controls was done. Materials and methods: A total of 227 subjects, 97 cases and 130 controls participated in the study. Level of total IgE and specifics IgE anti-As and anti-Dpt were investigated in all the subjects enrolled in the study. Results: Of the studied population, 211 children (93%) presented high total IgE. In the case group 75.3% were anti-Dpt IgE (+) and 64.9 % anti - As (+); in the control group the 76.2% were anti -Dpt IgE (+) and 74.6% anti - As IgE (+). The statistical association analysis showed that a high IgE becomes risk factor for asthmatic OR 5.73 (I.C 95%: 1.26 - 52.9) (p=0.023), whereas the intestinal parasite infection act like a protective factor, OR 0.44 (I.C. 95%: 0.24-0.80) (p=0.0049). anti-As IgE levels were significantly associated with IgE anti-Dpt levels (p<0.0001). Conclusions: This result can be explained by the presence of cross reactivity between its antigens. Not significant statistical association was found between the sensitization to Dpt or As with the asthma severity.

Palavras-chave : Asthma; cosensitization; intestinal parasitism; geohelminths, D.; pteronyssinus; Áscaris sp.

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