Abstract

GARCIA-TOLOSA, Raúl; MACHADO, Isidro; RUIZ, Lisette  and  LLOMBART-BOSCH, Antonio. Apocrine breast carcinoma: Morphologic and inmunohistochemical analysis of invasive pure and mix forms asociated or not with in situ carcinoma. Salud, Barranquilla [online]. 2009, vol.25, n.1, pp.101-117. ISSN 0120-5552.

Objetive:To recognize the morphologic and inmunohistochemical aspects of cases of apocrine mamary carcinomas. Matherials and methods:Twenty four cases of apocrine mamary carcinomas and ductal mamary carcinomas with apocrine diferetiation (mix apocine carcinomas) were studied morphologically and inmunohistochemically detected androgen receptor (AR), progesterone receptor (PR), gross cystic disease protein-15(GCDFP-15), BCL2, KI67 and CERB-2 in infiltrative and in situ areas of the same tumor and adicionally demonstrated the gene amplificacion of ERB-2 in the 17 cromosome by FISH analysis. Results: Eleven cases of pure apocrine carcinomas were encountered,inmunohistochemically positivity was as follows: AR (100%), ER (18%), PR (18%),GCDFP(63%)BCL2 (54%), KI67 (28%), and ERB-2(28%) with positivity of GCDFP-15(100%) over in situ areas; the rest 13 cases of mix apocrine carcinomas expresed positivity as follows: AR (58%), ER(46% ), PR(46% ), GCDFP-15(50%), BCL-2(33%), KI67(58%) and ERB-2(16%). In situ areas expresed of GCDFP-15 in all cases (100%) with a reduccion of the expression in the infiltrating areas of the same case to 63% and 50% of pure and mix tumors respectivilly. Conclution: Pure apocrine carcinoma most be distinguied of the mi apocrine forms of ductal and lobular carcinomas by a gently morfologic analysis of the tumor and the following combination would allow for and immunohistochemical identification: AR+, ER-, PR.

Keywords : Apocrine breast carcinoma; inmunohistochemical; androgen receptor.

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