Revista Salud Uninorte
On-line version ISSN 2011-7531
ANAYA CHAVEZ, Yosed and MARTINEZ, Beatriz. Genome-wide association studies (gwas) and its contribution to the genetic of asthma. Salud, Barranquilla [online]. 2010, vol.26, n.2, pp. 223-231. ISSN 2011-7531.
Despite all the efforts of more than a decade, the genetic basis of many common and complex diseases are still unknown, without demerit the remarkable progress that has been made with the linkage studies in families and association studies of candidate genes. Recently, development of more robust methodologies, like genome-wide associations studies (GWAs), has allowed to replicate previously reported associations and at the same time discovers new possibly associated genes. The GWAs are based on the use of a considerable number of genetic markers like SNPs or STRs which are searched in order to of associate them with the appearance or development of certain diseases. Given the large current impact of the GWAs as genetic tool in the search of associations this is a theoretical review on the design and interpretation of results and contribution of GWAs in asthma and related phenotypes.
Keywords : GWAs; Asthma; IgE,; Genetics markers; Complex diseases; SNPs.