Resumo

HERNANDEZ BUSTOS, Oscar Emilio  e  HERNANDEZ BUSTOS, Lilibeth. Relationship between Hodgkin and Huxley style sodium and potassium conductances and their effect on the propagation of action potentials at 40°C. Salud, Barranquilla [online]. 2011, vol.27, n.2, pp.223-235. ISSN 0120-5552.

Objetive: To determine from computational simulation, the response of an unmielynate axon to a constant current stimulus for different HH style maximum sodium (G_N) and potassium (G_K) conductance in the space G_Navs. G_Ksuch that 0S/cm²<G_Na<6.4S/cm² and 0S/cm²<G_K<2S/cm² at 40C Methodology: The propagation of action potentials along a neuronal structure called neurox was simulated using the software NEURON. Passive properties and HH style sodium and potassium channels whose opening and closing rates were corrected with the thermic coefficient, were inserted in neurox. Results: There is a region of dots in the space G_Navs. G_Kthat are limited by the lines and on which one unique action potential is spread along the neurox at 40°C. Conclusion: HH style sodium and potassium conductance can exist in neurons that work at 40°C, with diverse possibilities of combinations of G_Naand G_Kthat overcome the restrictions imposed by increment of speed in the opening and closing of the corresponding channels. This work established a methodological reference for exploring other areas of combinations of conductances.

Palavras-chave : HH style sodium and potassium conductance; temperature; simulation; propagation; action potential.

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