Abstract

CERVANTES PARRA, Luis; LONDONO OROZCO, Alfonso; NIETO GARCIA, Marco  and  GUTIERREZ DE AGUAS, Ricardo. Embryonic processes and congenital malformations. Review with case reports. Salud, Barranquilla [online]. 2012, vol.28, n.1, pp.150-161. ISSN 0120-5552.

The fundamental processes of embryonic dynamics in the animal kingdom and particularly in vertebrates are due to a genetic program that has begun to be understood in recent years. One of the developmental biologists' main goals is to unravel the mystery of how after being fertilized an oocyte becomes a multicellular organism. This dynamic requires activation of a complex development program in which genes are expressed in a temporal, precise sequence and in the correct location to give rise to different types of tissues such as skin, muscles and nerves among others. The genes involved in the embryo development pattern, active in females, have been identified by studying Drosophila mutants. Also, thanks to molecular techniques, advances in understanding the intricate mechanism that control this process have been significant in recent years. This work raises several issues related to teratogenicity associated with gastrulation, embryonic stage sensitive to damages. Also, this work provides study cases and a review of the progress in the understanding of molecular processes involved in embryonic dynamics.

Keywords : Embryonic development; congenital malformations; embryonic dynamic; molecular process.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )