Resumo

FERREIRA-SARMIENTO, Susana; LASTRA-TERAN, Katya P; DE LA ROSA, Dereck  e  VIASUS, Diego. Severe Chikungunya virus infection. Salud, Barranquilla [online]. 2015, vol.31, n.3, pp.631-641. ISSN 0120-5552.  https://doi.org/10.14482/sun.31.3.7352.

Recent publications have challenged the conventional view of the benign nature of the Chikungunya virus (CHIKV) infection. The clinical manifestations are highly variable and can be severe in some cases. Studies suggest that the severe form of CHIKV infection may be associated with multiple organ failure, hepatitis, meningitis, nephritis, encephalitis, bullous dermatitis, myocarditis, cardiac arrhythmias, among others. The underlying pathophysiology for some of these complications remains unclear. However, according to the clinical characteristics of severe or atypical cases reported to date, the development of complications could be grouped into three main categories, such as exacerbation of underlying medical conditions, deterioration of a previously unrecognized condition and inadequate immune response to infection. Some studies have found association between severe manifestations of infection and high levels of cytokines or some specific genomic sequences CHIKV. Experimental studies suggest that passive immunotherapy can be an effective strategy for the management of individuals at risk of severe CHIKV infection. Currently there is no clinical evidence to support antiviral drug use in the prevention or treatment of the disease.

Palavras-chave : Chikungunya; gravedad; mortalidad; biomarcadores; tratamiento.

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