Abstract

RODRIGUEZ SANJUAN, Alexander; CERVERA, Eliana; VALENCIA VILLA, Gerardo  and  VILLALBA AMARIS, Pedro J. Review: Neuronal and glial biomarkers as quantitative approach to classify the severity of traumatic brain injury. Salud, Barranquilla [online]. 2016, vol.32, n.2, pp.302-318. ISSN 0120-5552.

Abstract It has been highlighted the potential of early neurological inaccurate assessment of severity in patients with head trauma; in some cases, for example, the severity of the injury is overestimated or underestimated. The aforementioned situation has led to the search of biomarkers associated with early brain injury. Research in this field has exponentially increased over the past 20 years, with a higher publication ramp in the last 10 years. The results range from promising findings to other sometime inconclusive. An ideal biomarker should be able to demonstrate high sensitivity and specificity for brain injury, among others aspects. Literature has shown that there is not a single biomarker that can predict patient's clinical decline with high sensitivity and specificity correlation. Instead, it is required to use a panel of markers that reflect different aspects of traumatic brain injury. In this paper, we conducted a review of the most promising biomarkers studied as predictors of severity of head trauma, with special focus on their nature, location, basal concentrations, blood half-life and methods by which they can be quantified in blood samples.

Keywords : traumatic brain injury; biomarkers; prognosis; traumatic brain bleeding.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )