SciELO - Scientific Electronic Library Online

vol.34 issue1Anxious state before an evaluation in dentistry studentsEducational strategy with multimedia technologies to promote mental health in health students author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google


Revista Salud Uninorte

Print version ISSN 0120-5552On-line version ISSN 2011-7531


HERNANDEZ, Oscar E; ZUREK, Eduardo E; VERA, David  and  CEPEDA-EMILIANI, Alfonso. Effect of temperature in bursting of thalamic reticular cells. Salud, Barranquilla [online]. 2018, vol.34, n.1, pp.11-24. ISSN 0120-5552.


To show the relation between the four parameters associated to bursting discharges of the thalamic reticular cells (TRNn): the maximum firing frequency (fmax) and the temperature at which it occurs (Tfmax), the range of temperatures defined as the full width at half maximum (∆Th) and the maximum specific low threshold calcium conductance (GT).

Materials and Methods:

In order to simulate the TRNn bursting activity, a computational simulation model was implemented using the NEURON software, which incorporates morphological and electrophysiological data, and stimuli properties closely related to reality.


It was found that there are nonlinear relations between the parameters. The fmax frequency follows a quadratic growth with temperature and tends asymptotically towards a limit value with the maximum calcium conductance. In the same manner, ∆Th increases until reaching a limit value as function of fmax and GT. However, the increment per frequency unit is bigger than the increment per conductance unit.


Four equations were obtained that model the relations between the parameters associated to bursting discharges of the TRNn in rats and other neurons with similar characteristics in different animal species.

Keywords : TRN neuron; Computational simulation; Firing frequency; Temperature; Burst firing.

        · abstract in Spanish     · text in English     · English ( pdf )