Objective:

To show the relation between the four parameters associated to bursting discharges of the thalamic reticular cells (TRNn): the maximum firing frequency (fmax) and the temperature at which it occurs (Tfmax), the range of temperatures defined as the full width at half maximum (∆Th) and the maximum specific low threshold calcium conductance (GT).

Materials and Methods:

In order to simulate the TRNn bursting activity, a computational simulation model was implemented using the NEURON software, which incorporates morphological and electrophysiological data, and stimuli properties closely related to reality.

Results:

It was found that there are nonlinear relations between the parameters. The fmax frequency follows a quadratic growth with temperature and tends asymptotically towards a limit value with the maximum calcium conductance. In the same manner, ∆Th increases until reaching a limit value as function of fmax and GT. However, the increment per frequency unit is bigger than the increment per conductance unit.

Conclusions:

Four equations were obtained that model the relations between the parameters associated to bursting discharges of the TRNn in rats and other neurons with similar characteristics in different animal species.

        · resumo em Espanhol     · texto em Inglês     · Inglês ( pdf )