Objetive:

Evaluate the antimicrobial activity of calcium hydroxide in combination with omeprazole at different concentrations, against Enterococcus faecalis.

Materials and methods:

An in vitro experimental study in which the antimicrobial activity of calcium hydroxide and calcium hydroxide plus omeprazole at different concentrations (1 %, 5 %, 8 %, and 10 %) was tested against E. faecalis, determining the antimicrobial sensitivity in each of the groups. Statistical analysis of the data was performed using the Shapiro-Wilk statistical test and then the non-parametric Mann-Whitney test was used.

Results:

A remarkable sensitivity of the bacteria to omeprazole was observed, which increased as the concentration of omeprazole increases. The calcium hydroxide group plus omeprazole at 10 % had the highest percentage of inhibition (87.7) then 8 % with (71.9), 5 % (67.8) and 1 % (64.1).

Conclusions:

There is a significant increase in the antimicrobial activity of calcium hydroxide combined with omeprazole against Enterococcus faecalis.

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