Resumo

MORENO MARTINEZ, David; NINO CASTRO, Andrea Cecilia  e  PUSTOVRH, María Carolina. Enzyme indoleamine 2,3-dioxygenase 1: physiopathological implications during gestation in obesity conditions. Salud, Barranquilla [online]. 2019, vol.35, n.2, pp.277-297. ISSN 0120-5552.  https://doi.org/10.14482/sun.35.2.618.

Women who have an obese body mass index are more likely to experience pregnancy complications, including spontaneous abortion and preeclampsia. It has been suggested that these complications are at least in part related to the pro-inflamatory environment that predominates in obesity. Indoleamine-2,3-dioxygenase 1 is an enzyme induced downstream IFN-y signalling, hence it has been suggested that it increases its expression and activity in obese patients. IDO1 exerts multiple functions in pregnancy, including its contribution to materno-fetal tolerance, placentation and regulation of placental blood flow. The evidence about IDO1 in pregnant obese women is scarce. Therefore, herein the implications of an overexpression of IDO1 in pregnant obese patients were explored. The evidence available at the moment suggests that it is possible that IDO1 increases its expression and activity in pregnant obese women contributing to the complications observed on these patients.

Palavras-chave : obesity; gestation; indoleamine-2,3-dioxygenase 1; pregnancy complications.

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