Abstract

LLEBISCH-REY, HANS et al. Worldwide Overview of the Different COVID-19 Vaccine Platforms: A Review and Reflection on the Current Evidence. Salud, Barranquilla [online]. 2021, vol.37, n.1, pp.162-188.  Epub Feb 28, 2022. ISSN 0120-5552.  https://doi.org/10.14482/sun.37.1616.241.

Vaccines are biological products containing antigens that aim to generate protection against real exposure to an infectious pathogen. They constitute the most cost-effective interventions in public health, being surpassed only by drinking water. Generally speaking, we can divide the vaccines into live attenuated and inactive; However, the new coronavirus has produced innovative platforms that use intracellular and molecular mechanisms with the same objective of generating immunity.

A systematic literature search was carried out using the PUBMED, SCOPUS, and Web of Science electronic databases. All types of study design were selected, those written in English or Spanish were prioritized. We reviewed the existing platforms to generate immunity against the SARS-CoV-2 coronavirus. Each one is developed according to its route and form of action, and can be classified as protein subunits, recombinant viral vector, nucleic acids, inactivated viruses, viral particles, and live attenuated viruses.

The mechanisms by which these vaccines generate immunogenicity are different; however, the constant insertion of mutations by the virus remains an object of interest and concern for researchers.

Keywords : SARS CoV-2; COVID-19; Vaccines; Mutagenesis; Genomic Surveillance; Pharma-covigilance.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )