Abstract

PORTILLO-MINO, JOSÉ DARÍO; CARLOSAMA-ROSERO, YEISON HARVEY; MELO-YEPEZ, JORGE MAURICIO  and  MERA-MARTINEZ, PAULO FRANCISCO. Giant GIST of High-risk Criteria: Case Report and Literature Review. Salud, Barranquilla [online]. 2021, vol.37, n.3, pp.880-892.  Epub May 23, 2022. ISSN 0120-5552.  https://doi.org/10.14482/sun.37.3.616.33.

Gastrointestinal stromal tumors (GIST) are the most common mesenchymal neoplasms of the digestive tract. Risk staging criteria such as angioinvasion, size, infiltration, and mitotic index allow for adequate diagnosis and treatment. A 67-year-old male patient is presented, who consulted for hematemesis and melena. Endoscopically, a 20x10x6 cm diameter mass was observed in the stomach, which was taken for a biopsy for study. On histopathological examination, a GIST with the microscopic invasion of the lamina propia and angioinvasion was diagnosed. These two histopathological components are scarcely taken into account to classify GIST; however, they are very important in this context, changing the prognosis of the disease and requiring adjuvant therapy with imatinib. The outcome of the patient was favorable due to the established therapeutic conduct. The biological behavior of GIST varies depending on the clinical and histopathological characteristics. This case highlights the high-risk criteria for GIST and the need to modify the treatment when present.

Keywords : GIST; stomach; risk stratification; imatinib.

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