SciELO - Scientific Electronic Library Online

 
vol.28 issue2Using multinomial and imprecise probability for non-parametric modelling of rainfall in Manizales ( Colombia )Oxidising agent and catalyst chirality effect on epoxidation of R-(+)-Limonene using Jacobsen-type catalysts author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Article

Indicators

Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google

Share


Ingeniería e Investigación

Print version ISSN 0120-5609

Abstract

VARGAS E., Edgar F.; BARBOSA B., Helber J.  and  MARTINEZ, Fleming. The Jouyban-Acree model’s usefulness for estimating ibuprofen and naproxen solubility in some cosolvent mixtures. Ing. Investig. [online]. 2008, vol.28, n.2, pp.30-36. ISSN 0120-5609.

Estimating drug solubility in cosolvent mixtures has been an important pharmaceutical science research field at theoretical and practical levels for several decades. The validity of an adapted version of the Jouyban-Acree (J-A) model for predicting ibuprofen (IBP) and naproxen (NAP) solubility in propylene glycol + water cosolvent mixtures was thus evaluated. The usefulness of Yalkowsky and Roseman’s solubility log-linear equation was also evaluated for the same drugs in such cosolvent system. The solubility estimation was studied as a function of temperature and cosolvent composition. The J-A and Y-R models only require experimental equilibrium solubility values in pure solvents at all temperatures evaluated. Estimated solubility values obtained by using both semi-empiric models were similar but presented notable deviations regarding experimental values presented in the literature, especially for IBP. These results show that currently available theoretical strategies for estimating this property must be improved; they also demonstrate the importance of experimental determination of drug solubility according to temperature in all cosolvent mixtures which could be useful when designing homogeneous liquid dosage at industrial level.

Keywords : ibuprofen; naproxen; cosolvent mixture; Jouyban-Acree equation.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License