Revista Colombiana de Cardiología
versão impressa ISSN 0120-5633
VELASQUEZ, Óscar et al. Autologous intramyocardial transplant of bone marrow derived stem cells for revascularization in ischemic chronic cardiopathy. Rev. Col. Cardiol. [online]. 2005, vol.12, n.2, pp. 80-84. ISSN 0120-5633.
Introduction: experimental and clinical studies have demonstrated that intramyocardial bone marrow derived stem cells implantation produce angiogenesis and improvement of cardiac function in patients with chronic ischemic cardiopathy. Methodology: this is a two months follow-up report of a patient with chronic ischemic cardiopathy not susceptible of surgical or percutaneous revascularization, to whom bone marrow stem cells mobilized with granulocyte - macrophage growth factor was implanted. Results: significant improvement was demonstrated in symptomatology, functional capacity (1.8 Mets to 10 Mets), functional state (IV to I), size of the myocardial perfusion defect by nuclear medicine, in the ejection fraction and diminution of the final left ventricular systolic volume, without complications related to the procedure. Conclusion: bone marrow derived stem cells transplant is an effective and safe therapy in order to promote neo-vascularization and improve contractility and myocardic perfusion in patients with chronic ischemic cardiopathy considered poor surgical candidates.
Palavras-chave : ischemic cardiopathy; stem cells; intramyocardic; angiogenesis; bone marrow.