Abstract

HENAO, Oscar; FERRERO, José M; RAMIREZ, Eduardo  and  SAIZ, Javier. Cardiac arrhythmias generated by electrophysiological heterogeneity: simulation study. Rev. Col. Cardiol. [online]. 2007, vol.14, n.4, pp.185-197. ISSN 0120-5633.

Ventricular arrhythmias usually appear as consequence of acute myocardial ischemia, responsible for most of sudden deaths. Functional (different electrical behavior of myocytes) as well as biochemical (different ionic concentrations during ischemia) cardiac heterogeneity alter the ventricle electric performance and generate dispersion in the action potential repolarization that turns into functional substrate for the generation of fatal arrhythmias. In this work the experimental techniques for the study and detection of arrhythmias by re-entry are reviewed and a geometrical model of ischemia is validated in the presence of electrical heterogeneity in the trans-mural region of the ventricular wall. For this purpose, bi-dimensional simulations of a detailed biophysical model were used and lobular re-entries in different configurations of the M cells of the ventricular wall were obtained.

Keywords : ventricular arrhythmias; M cells; cellular heterogeneity; regional ischemia; transmural wall; potential re-entries.

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