Abstract

AGUDELO O, Gloria M et al. Effect of consumption of different doses of filtered coffee on homocysteine plasma levels and blood pressure in a group of healthy volunteers. Rev. Col. Cardiol. [online]. 2008, vol.15, n.2, pp.65-74. ISSN 0120-5633.

It is not clear if coffee consumption affects blood pressure and homocysteine levels. The objective of this study was to determine the variations in homocysteine plasma levels and blood pressure in a group of healthy volunteers. A prospective controlled clinical trial was performed; four groups of 29 patients each one were comprised and they were submitted to filtered coffee consumption during a six weeks period. Group 1 did not consume coffee; group 2 consumed 200mL coffee; group 3 consumed 400 mL and group 4 , 600 mL. Blood pressure, homocysteine levels, arterial index, erythrocyte folic acid and B12 and B6 vitamins were measured. The outcomes showed no significant differences between the groups in basal conditions. After the intervention, change in homocysteine levels between the groups did not show any significant difference and remained within the reference values (p = 0,098). Change in systolic and diastolic arterial pressure levels was not significant (p = 0,510 and 0,430 respectively). In conclusion, different filtered coffee doses consumption didn’t show significant changes in homocysteine plasma levels, nor in systolic and diastolic arterial pressure ciphers in a group of healthy normotense subjects; in the group that did not consume coffee, homocysteine levels and blood pressure had no significant decrease in these values.

Keywords : homocysteine; blood pressure; cardiovascular risk.

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