Abstract

ECHEVERRI, Darío. Biological effects of drug-eluting stents in the coronary circulation. Rev. Colom. Cardiol. [online]. 2010, vol.17, n.2, pp.47-55. ISSN 0120-5633.

Drug-eluting stents offer the best available non-surgical alternative for the treatment of coronary disease, thanks to its demonstrated efficacy. However, in terms of security, these excellent results have been overshadowed by the late or very late appearance of stent thromboses.The biological effects they have in the coronary artery after its implantation are due to the effect of the platform used, the polymer and the medication released. The vascular healing disorders induced by drug-eluting stents favor stent thrombosis and its clinical consequences. This is a review of the different biological effects of drug-eluting stents in coronary arteries that allows to understand how the rapid onset of new versions of materials, designs, polymers and medications diminish adverse coronary effects and improve its efficacy and safety.

Keywords : stents; thrombosis; endothelium; inflammation; coronary heart disease.

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