Abstract

SALAZAR, Lukas; PALACIO, Ana Cristina  and  RODRIGUEZ, Javier R. Mechanisms of cardiotoxicity: antineoplastics, nonsteroidal anti-inflammatory drugs, antipsychotics, cocaethylene and sympathomimetics. Rev. Colom. Cardiol. [online]. 2011, vol.18, n.2, pp.100-110. ISSN 0120-5633.

The constant interaction of the human body with different substances that are even in many cases considered harmless has a high impact on all systems, being the cardiovascular system one of the most affected. Therefore, it is vital to recognize the mechanisms by which these substances exert their toxic effect on this system, either affecting the membrane stability and the contractile function, or generating intracellular organelles dysfunction and oxidative stress. Numerous studies have found that drugs which have been widely used for many years such as clozapine and catecholamines, have harmful effects. Research is still being done seeking to clarify the cardiotoxic mechanisms of drugs commonly formulated, including anticancer and non steroidal anti-inflammatory drugs (NSAIDs), as well as commonly used substances that cause addiction, such as alcohol, cocaine and cocaethylene, its active metabolite.

Keywords : cardiotoxicity; arrhythmogenesis; myocardial injury; antineoplastics; nonsteroidal anti-inflammatory drugs; cocaethylene; clozapine; catecholamines.

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