Resumo

MANZUR, Fernando; ALVEAR, Ciro  e  ALAYON, Alicia Norma. Role of C-reactive protein in cardiovascular diseases. Rev. Colomb. Cardiol. [online]. 2011, vol.18, n.5, pp.273-278. ISSN 0120-5633.

C-reactive protein (CRP), a sensitive marker of inflammation is an independent predictor of future cardiovascular disease (CVD), which is one of the main causes of death worldwide. The role of inflammation in cardiovascular disease has been well documented in the last decade, and inflammation has been demonstrated in all stages of atherosclerosis, from its beginning and growth to the plaque rupture. CRP is an acute phase protein, highly sensitive as a marker of general inflammation. The presence of CRP has been determined in experimental studies in arteries with atherosclerotic lesions. It has been demonstrated as well that CRP induces directly the production of other inflammatory cells and decreases the expression of nitric oxide synthase. This means that from the biological standpoint CRP takes part in the atherogenic process. In adults, CRP detected through high sensitive CRP-test (hs-CRP) is associated to traditional risk factors and its concentration predicts cardiovascular events.

Palavras-chave : C-reactive protein; risk factors; adiposity; obesity.

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