Abstract

HOLGUIN, Héctor; CEBALLOS, Mauricio  and  AMARILES, Pedro. Clinical relevance of clopidogrel and omeprazole interaction: systematic review. Rev. Colomb. Cardiol. [online]. 2012, vol.19, n.1, pp.25-32. ISSN 0120-5633.

Objective: to perform a structured review of the clopidogrel and omeprazole interaction, establish its clinical relevance and generate practical recommendations on the subject. Method: a structured review on PubMedLine of studies published in the last ten years, using clopidogrel AND omeprazole as strategy. The information was grouped and complemented according to the method used to quantify the effect and with the determination of a possible class effect. Results: the search generated 35 articles, of which 18 were included (five assessed the in-vitro interaction, six the in-vivo interaction and ten analyzed the interaction as a class effect). Seven studies reported loss of the platelet anti-aggregation effect, while three found no significant alteration of the effect. Conclusions: the evidence of the clinical relevance of clopidogrel and omeprazole interaction is nor conclusive. It is recommended to follow the regulatory agencies indications, and in some cases replace omeprazole for pantoprazole.

Keywords : platelet anti-aggregation; clopidogrel; drug interaction; omeprazole.

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