Abstract

JARAMILLO, Manolo I et al. Insertion/deletion polymorphism of the angiotensin converting enzyme gene and coronary artery disease in the population of Monteria, Cordoba. Rev. Colomb. Cardiol. [online]. 2013, vol.20, n.5, pp.278-284. ISSN 0120-5633.

Background and Objective: the insertion/deletion polymorphism of the gene for angiotensin converting enzyme has been identified as a potent risk factor for coronary heart disease. For the population of Monteria, the frequency with which the alleles of this gene are expressed and the nature of its interaction with cardiovascular risk conditions, are not known. The aim of this work was to determine the association of this polymorphism and the risk of coronary heart disease in this population. Methods: a retrospective study of 70 cases and 70 controls was conducted. Cases were the patients with coronary disease confirmed by electrocardiogram , reported to the Cordoba Cardiodiagnosis Organization and the control ones were volunteers without history of cardiovascular disease and without filial relationship. Required DNA was extracted from peripheral blood. Polymorphism characterization was done by the polymerase chain reaction. Results: the distribution of genotypes of the angiotensin converting enzyme gene in patients cases was not significantly different from that estimated in control patients (X2 = 3.687, p = 0.1583). The most common genotype in the population was ID (40.72%). In the group cases, genotype II was more frequent than the DD genotype compared with the control group (p < 0,05). The multiple logistic regression adjusted model indicated no significance of DD genotype as coronary risk factor (odds ratio = 0.51 95% CI = 0.25 to 1.06). Conclusion: I/D polymorphism of the angiotensin converting enzyme gene did not show to be a significant risk factor for coronary heart disease in the population of Monteria.

Keywords : coronary artery disease; polymorphism insertion / deletion of the angiotensin converting enzyme gene; cardiovascular risk factors.

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