Abstract

STORINO, Marcelo A et al. Complications of diabetes and its association with oxidative stress: a journey to the endothelial damage. Rev. Colomb. Cardiol. [online]. 2014, vol.21, n.6, pp.392-398. ISSN 0120-5633.  https://doi.org/10.1016/j.rccar.2014.09.004.

Diabetes is a metabolic disorder that has increased in Latin America and Venezuela over the last decade. It exerts an important influence on cardiovascular diseases morbi-mortality because of the hydrocarbonate imbalance and on patients outside ADA's 2012 goals, with risk factors such as hypertension and dyslipidemia. Diabetes is a state of oxidative stress where there is an imbalance between excessive formation and insufficient removal of highly reactive molecules such as reactive oxygen species (ROS) and reactive nitrogen species (RNS). Oxidative stress plays an important role in developing diabetes complications because excessive oxidative activity. Endothelial dysfunction is defined as alterations affecting synthesis, liberation, diffusion or degradation of the factors synthesized by the endothelium. The intrinsic mechanism that drives endothelial cells to switch their physiologic phenotype into an activation state mistakenly known as dysfunction is the ability to express O₂ production enzymatic systems. Drugs that modulate incretin pathway (GLP-1 and DPP4 inhibitors) are characterized by their low incidence of hypoglycemic effect, which increases their safety. Recent studies with GLP-1 have shown its ability to reverse oxidative stress produced by hyperglycemia, hypoglycemia and the transition from hypo to hyperglycemia.

Keywords : Free radical; Diabetes mellitus; Endothelium; Glucose; Vessels; Inflammatory response.

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