Resumo

GARCIA, Ángel A. et al. Therapeutic alternatives to pharmacological management with statin drugs in adults with dyslipidemia. Systematic literature review and general recommendations. Rev. Colomb. Cardiol. [online]. 2015, vol.22, n.4, pp.179-186. ISSN 0120-5633.  https://doi.org/10.1016/j.rccar.2015.04.004.

Objective To evaluate the impact on the incidence and recurrence of cardiovascular and cerebrovascular events (primary and secondary prevention), the levels of lipid fractions and the incidence of side effects in people with hypercholesterolemia intolerant to statin therapy. Methods: A clinical practice guideline was developed following the guidelines of the methodological guidance of the Ministry of Health and Social Protection to systematically collect the evidence and make recommendations using the GRADE methodology. Population: Adult population, diagnosed with dyslipidemia or at risk of developing, intolerant to management with statin drugs. Recommendations: Recommendations for the use of different medications (fibrates, niacin, omega 3 acids, bile acid binding resins, ezetimibe) are formulated according to their lipid-lowering effectiveness and reduction of cardiovascular events, a proposal adapted to the Colombian social context.

Palavras-chave : Cardiovascular disease; Hypercholesterolemia; Lipids; Treatment; Statins.

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